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Articles

Genetic ancestry and population structure in the All of Us Research Program cohort - Nature Communications

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By Shivam Sharma, Stephan L. Zuchner, Leonardo Mariño-Ramírez, Robert Meller, SEEC Consortium
| Nature Verified
Abstract We analyzed participant genomic variant data to characterize population structure and genetic ancestry for the All of Us cohort (n = 297,549). There is substantial population structure in the cohort, with clusters of closely related participants interspersed among less related individuals. Participants show diverse genetic ancestry, with major contributions from European (66.4%), African (19.5%), Asian (7.6%), and American (6.3%) continental ancestry components.
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