Seicho Makihira on Muck Rack

Seicho Makihira

As seen in: The Journal of Immunology
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Articles

Soluble RANKL Cleaved from Activated Lymphocytes by TNF-α-Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis

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By Hiroyuki Kanzaki, Seicho Makihira, Maiko Suzuki, Takenobu Ishii
| The Journal of Immunology Verified
Host immune responses play a key role in promoting bone resorption in periodontitis via receptor activator of NF-?B ligand (RANKL)–dependent osteoclastogenesis. Both membrane-bound RANKL (mRANKL) expressed on lymphocytes and soluble RANKL (sRANKL) are found in periodontal lesions. However, the underlying mechanism and cellular source of sRANKL release and its biological role in periodontitis are unclear. TNF-?–converting enzyme (TACE) is reported to cleave the following: 1) precursor TNF-?
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