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Osteoporosis is a global public health problem that affects more than 200 million individuals, with a total of 1.66 million hip fractures annually (1). One in 3 women and 1 in 5 men over the age of 50 years will experience an osteoporotic fracture in their lifetime (2). Primary osteoporosis is most common and occurs during the normal aging process related to menopause and changes in sex hormones that occur with advancing age.
Vitamin D deficiency is common in individuals with cystic fibrosis (CF) due to impaired absorption of fat-soluble vitamins, decreased sunlight exposure, and suboptimal intake of vitamin D-containing foods and/or supplements (1). Vitamin D deficiency in CF has been associated with decreased bone mass in children, failure to achieve expected peak bone mass in young adults, and osteoporosis in mature adults, and it may impact other comorbidities common in CF (2–4).
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