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Sélène Forget

As seen in: BioRxiv
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Articles

Critical structural perturbations of ribozyme active sites induced by 2'-O-methylation commonly used in structural studies

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By Sélène Forget, Guillaume Stirnemann
| BioRxiv
Abstract Most naturally occurring ribozymes catalyze self-splicing reactions through a 2'-OH group. Consequently, experimental structures of precatalytic states often require chemical modifications of the 2'-OH, such as its removal or methylation. However, the impact of these chemical modifications on the active site structure remains largely unexplored, which raises important questions since methylated structures are often taken as being representative of pre-catalytic states.
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[2503.19067] Clustering data by reordering them

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By Sélène Forget, Aliénor Lahlou, Camille Berthelot, Claire Lavergne
| arXiv
arXiv:2503.19067 (cs) View PDF HTML (experimental) Comments: Subjects: Computer Vision and Pattern Recognition (cs.CV); Biomolecules (q-bio.BM) Cite as: arXiv:2503.19067 [cs.CV] (or arXiv:2503.19067v1 [cs.CV] for this version) https://doi.org/10.48550/arXiv.2503.19067 Submission history From: Nicolas Chéron [ view email] [v1] Mon, 24 Mar 2025 18:54:00 UTC (18,243 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Connected Papers Toggle Connected Papers (What is...
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Simulation-Guided Conformational Space Exploration to Assess Reactive Conformations of a Ribozyme

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By Elise Duboué-Dijon, Guillaume Stirnemann, Sélène Forget, Marie Juillé
| dx.doi.org
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