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Senami Furubayashi on Muck Rack

Senami Furubayashi

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Articles

Impacts of methotrexate on survival, dendrite development, and synapse formation of cortical neurons

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By Kenji Hanamura, Noriko Koganezawa, Mai Yamamura, Senami Furubayashi
| Wiley Online Library Verified
Abstract Methotrexate (MTX) is an anti-metabolite that has been used for the treatment of patients of acute lymphocytic leukemia or non-Hodgikin lymphoma for decades. In some cases, MTX-treated patients suffer from neurological side effects, including seizures and cognitive dysfunctions. While most patients are at developmental stages, information of the mechanisms of the side effects of MTX treatment on the developing neurons has been limited.
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