Senik Matinyan

Published July 12, 2024 | Version v1.0.1 Software Open 1. Biozentrum, University of Basel We updated the TRPX code. The TIFF library we wrote has a very little footprint, however it can not read all the possible TIFF formats available. In a scenario, when it gives warnings the TRPX prints them and stops the execution. We solved some small bugs in the header libraries as well. Name Size md5:f7508b205327ac3547f73a7d15f0827f 3.2 MB Software: https://github.com/senikm/trpx/tree/v1.0.1 (URL)

Abstract Introduction. Proteins that adopt multiple conformations pose significant challenges in structural biology research and pharmaceutical development, as structure determination via single particle cryo-electron microscopy (cryo-EM) is often impeded by data heterogeneity. In this context, the enhanced signal-to-noise ratio of single molecule cryo-electron diffraction (simED) offers a promising alternative.