Senuri De Silva

eLife Assessment This is a solid paper on intermittent fasting that will be of interest to readers. The data presented are certainly valuable as a resource. The findings of both shared and tissue-specific signatures, both at the proteomic and transcriptomic levels, align well with what has been established and bring new insight into metabolic adaptation and its consequences in muscle, cortex, and liver.

Abstract Reverse transcriptases (RTs) have well-established roles in the replication and spread of retroviruses and retrotransposons. However, recent evidence suggests that RTs have been conscripted by cells for diverse roles in antiviral defense. Here we determine structures of a type I-A retron, which explain how RNA, DNA, RT, HNH-nuclease and four molecules of an SMC-family ATPase assemble into a 364 kDa complex that provides phage defense.

1. Introduction Skin cancer is one of the most common cancers globally; melanoma causes the highest number of deaths annually. It is the most hazardous type of skin cancer that develops fast and spreads to other organs. The World Health Organization (WHO) has predicted nearly 7990 melanoma deaths in 2023, with an anticipated 97,610 new cases in the USA [1]. In order to avoid adverse results from the advent, prompt detection and treatment are required.