Seo Lyn Choi on Muck Rack

Seo Lyn Choi

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Articles

HERC1 oncogene enhances stemness and tumorigenic potential in CD44 + -derived organoids of head and neck squamous cell carcinoma through IL-6/STAT3 signaling

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By Eunjin Jeong, Seohee Park, Seojin Jang, Jamin Ku, Hajeong Kim, Haeun Kim, Suji Baek, Jung Park, Jae Lee, Sei Young Lee, Seok-Hyung Kim, Sang-Hyuk Lee, Hye Lin Kim, Seo Lyn Choi, Jeong-Yoon Yang, Jangok Yeo, Chang-Whan Yoon
| Nature Verified
Abstract HECT and RCC1-like domain-containing protein 1 (HERC1), a large E3 ubiquitin ligase, has been implicated in neural development and genome stability, but its role in cancer remains unclear. This study identifies HERC1 as a critical regulator of cancer stemness, metastasis, and chemoresistance in head and neck squamous cell carcinoma (HNSCC).
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