Seok-Mo Kim

CaMK2α calcium/calmodulin-dependent protein kinase alpha CSCs cancer stem cells ER endoplasmic reticulum FBS fetal bovine serum MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide qRT-PCR quantitative reverse transcription PCR RNA-Seq RNA sequencing RPMI-1640 Rosewell Park Memorial Institute-1,640 SERCA sarco/endoplasmic reticulum calcium ATPase siRNA small interfering RNA YUMC Yonsei University Medical Center What is already known?

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Abstract Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell death in ATC cells. However, glutamine metabolism inhibition triggered cell growth arrest independent of cell death in ATC, suggesting that other signaling pathways avoid glutamine metabolism inhibition-induced stress exist.