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Seong Hu Kim on Muck Rack

Seong Hu Kim

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Decoding gene responsiveness to synthetic chromatin reader-actuators with multi-modal epigenomic profiling

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By Natecia L. Williams, Rachel Fisher, Christopher Plaisier, Karmella Haynes, Seong Hu Kim, Isioma Enwerem-Lackland
| Nature Verified
Abstract Cell identity is regulated by chromatin states that encode gene regulatory memory and shape responses to new inputs. To investigate how chromatin context influences inducibility in differentiated cells, we employed engineered synthetic reader-actuators (SRAs), fusion proteins containing the polycomb chromodomain (PCD) that binds H3K27me3. In MCF7 breast cancer cells, we mapped PCD-fusion occupancy by ChIP-seq and used RNA-seq to identify temporally resolved gene activation patterns.
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