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Development of a Prophylactic mRNA Vaccine for Severe Fever with Thrombocytopenia Syndrome Using HSA based LNP - npj Vaccines

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By Hyeon Jin Kim, Tsenddari Ganbold, Enkhchimeg Lkhagva, Enkhtsatsral Munkhtur, Satabdi Acharya, Seong-Tschool Hong
| Nature Verified
Abstract Current lipid nanoparticles (LNPs) used in mRNA vaccines typically incorporate polyethylene glycol (PEG) as a stabilizing material; however, safety concerns have prompted the search for non-PEG alternatives. Severe Fever with Thrombocytopenia Syndrome (SFTS) is a life-threatening zoonotic disease with a case fatality rate of up to 30%, and its incidence is rising in East Asia, including China, South Korea, and Japan.
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