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Articles

Synthesis of 3-desoxycollinoketone B and its ability to reduce Alzheimer-associated misfolded proteins - Nature Communications

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By Minhae Cha, Wonho Zhung, Illhwan Cho, Wonbin Seo, Heewon Shin, Soljee Yoon, Suhyun Ye, Hayoung Hwang, Woo Youn Kim, young kim, Sunkyu Han, Seongrok Heo, Sirisuk Keereewan, MinSeol Park, Jae-Kyung Heo
| Nature Verified
Abstract Collinolactone, featuring a 7/10/6 tricyclic core, has been proposed to be biosynthesized via a transannular [6 + 4] cycloaddition reaction. Besides its intriguing architecture, collinolactone holds pharmaceutical promises due to its ability to disrupt amyloid-β (Aβ) and tau aggregation, which are specifically found as disease culprits in the brains of Alzheimer’s disease (AD) patients and are key targets in current drug discovery efforts.
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