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Seonmi Jo

As seen in: Nature, MDPI
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Articles

A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells

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By Heabin Kim, Hyun-Taek Kim, Seung-Hyun Jung, Seonmi Jo
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Effect of Copper Chelators via the TGF-β Signaling Pathway on Glioblastoma Cell Invasion

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By Heabin Kim, Seonmi Jo, In-Gyu Kim, Rae-Kwon Kim
| MDPI
Abstract : Glioblastoma multiforme (GBM) is a fast-growing and aggressive type of brain cancer. Unlike normal brain cells, GBM cells exhibit epithelial–mesenchymal transition (EMT), which is a crucial biological process in embryonic development and cell metastasis, and are highly invasive. Copper reportedly plays a critical role in the progression of a variety of cancers, including brain, breast, and lung cancers. However, excessive copper is toxic to cells.
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Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

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By Jong-Hyun Park, Byoung Joo Gwag, Heejung Chun, Seonmi Jo
| Nature Verified
Abstract Although the pathological contributions of reactive astrocytes have been implicated in Alzheimer’s disease (AD), their in vivo functions remain elusive due to the lack of appropriate experimental models and precise molecular mechanisms. Here, we show the importance of astrocytic reactivity on the pathogenesis of AD using GiD, a newly developed animal model of reactive astrocytes, where the reactivity of astrocytes can be manipulated as mild (GiDm) or severe (GiDs).
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