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Articles

Targeting glial PD-1/PD-L1 restores microglial homeostasis and attenuates neuronal hyperactivity in Alzheimer's disease model

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By Taeyoung Park, Leechung Chang, Seung Won Chung, Seowoo Lee
| biorxiv.org
Abstract Alzheimer's disease (AD) involves complex neuroimmune interactions. However, the role of immune checkpoint pathways in regulating the glial and neuronal functions of the AD brain remains unclear. This study aims to investigate how the brain-specific modulation of the PD-1/PD-L1 axis affects glial and neuronal function in an AD mouse model, which is characterized by the significant upregulation of microglial PD-1 and astrocytic PD-L1.
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Intracortical injection of immune checkpoint inhibitor promotes monocyte/macrophage infiltration and restores microglial function and neuronal activity in an AD mouse model

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By Taeyoung Park, Seung Won Chung, Leechung Chang, Seowoo Lee
| biorxiv.org
Abstract Understanding the intricate interplay among immune responses and homeostatic cell function in Alzheimer's disease (AD) remains challenging. Here, we present a novel strategy to mitigate AD pathology by directly modulating the immune checkpoint PD-1/PD-L1 signaling pathway in the brain, where elevated levels of microglial PD-1 and astrocytic PD-L1 have been observed.
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