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Introduction: We aimed to evaluate whether or not mitomycin-C (MMC) has an antifibrotic effect on transforming growth factor-beta (TGF-?)-induced Peyronie’s disease (PD) in a rat model. Methods: Eighteen 12-week-old male Sprague-Dawley rats were divided into three groups: Group 1=TGF-?1 (n=7); Group 2=TGF-?1+MMC (n=7); and Group 3=Sham group (0.25 ml bovine serum albumin injected) (n=4). All groups were sacrificed on the sixth week of the procedure and their penises were excised.
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