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Serena Barral on Muck Rack

Serena Barral

As seen in: Nature, MDPI, Science Magazine, BioRxiv, The Lancet
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Articles

An integrative mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression

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By Chris Finan, Sandesh Chopade, Marion van Vugt, Nikita Hukerikar, Serena Barral, Argyris Stringaris, Amand F Schmidt, Karoline B Kuchenbaecker, Jean-Baptiste Pingault, Abigail R. ter Kuile
| Nature Verified
Abstract Major depression (MD) treatments have limited efficacy and target few mechanisms, highlighting the need for innovative drug discovery. Drugs targeting genetically supported proteins are 2.6 times more likely to succeed in drug development. Here, we use genetic methods to identify and prioritise MD drug targets, leveraging genome-wide association study (GWAS) summary statistics from >525,000 MD cases.
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An in vivo and in vitro spatiotemporal atlas of human midbrain development

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By Serena Barral, Dimitri Budinger, George Hall, Julie Jerber
| BioRxiv
Abstract The dopaminergic system has key roles in human physiology and is implicated in a broad range of neurological and neuropsychiatric conditions that are increasingly investigated using induced pluripotent stem cell-derived midbrain models. To determine the similarity of such models to human systems, we undertook single cell and spatial profiling of first and second trimester fetal midbrain and compared it to in vitro midbrain models.
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Dopamine Transporter Deficiency Syndrome (DTDS): Expanding the Clinical Phenotype and Precision Medicine Approaches

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By Joanne Ng, Serena Barral, Simon Waddington, Manju A. Kurian
| MDPI
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