Serena Mares Malta

Abstract Alzheimer’s disease is characterized by progressive neurodegeneration driven by β-amyloid (Aβ) toxicity, oxidative stress, and cholinergic dysfunction. In this study, we investigated whether polar metabolites derived from a cultivable bacterial isolate could modulate Aβ-associated neurodegenerative phenotypes in complementary experimental models. A bioactivity-guided approach identified an aqueous fraction with high antioxidant capacity in DPPH, FRAP, and ORAC assays.

1 Introduction Metallic nanoparticles are highly versatile in biomedicine due to their small size, being employed in drug delivery, diagnostic applications, and therapeutic treatments [1]. Gold nanoparticles (AuNPs) are distinguished by their versatility across a broad spectrum of applications, including imaging, therapy, and sensing, owing to their tunable optical and electronic properties as well as their stable and well-established biocompatibility [2-4].