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Keywords cell migration actin cytoskeleton Ca2+ signaling RhoA lamellipodia TRPV4 CaMKII cell protrusion TEM4 Arhgef17 Get full text access Log in, subscribe or purchase for full access. References 1. SenGupta, S. ∙ Parent, C.A. ∙ Bear, J.E. The principles of directed cell migration Nat. Rev. Mol. Cell Biol. 2021; 22:529-547 2. Yamada, K.M. ∙ Sixt, M. Mechanisms of 3D cell migration Nat. Rev. Mol. Cell Biol. 2019; 20:738-752 3. Leithner, A. ∙ Eichner, A. ∙ Müller, J. ...
Abstract The interrelationship between microtubules and the actin cytoskeleton in mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that the effects of microtubules on two major types of cell-matrix adhesion, focal adhesions and podosomes, are mediated by KANK family proteins connecting the adhesion protein talin with microtubule tips.
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