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Sergi Guerrero Llobet on Muck Rack

Sergi Guerrero Llobet

As seen in: Nature
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Articles

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

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By Rico D. Bense, Mieke C. Zwager, Sergi Guerrero Llobet, Evelien Jongeneel
| Nature Verified
Abstract Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells, an important cause of replication stress is oncogene activation. Importantly, tumors with high levels of replication stress may have different clinical behavior, and high levels of replication stress appear to be a vulnerability of cancer cells, which may be therapeutically targeted by novel molecularly targeted agents.
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