Sérgio Araújo Andrade

Abstract A review of the principal clinical applications of antimicrobial photodynamic therapy (aPDT) in dentistry. To provide an overview of clinical applications and future perspectives of aPDT in dentistry. A comprehensive search was conducted on PubMed, Web of Science, Scopus, and Embase up to September 2022, where only data from randomized clinical trials were included. In vitro studies, animal studies, literature reviews, and duplicate articles were excluded from the review.

Abstract A review on antimicrobial resistance mechanisms discussing the main light-based antimicrobial approaches including ultraviolet light (UV), antimicrobial photodynamic therapy (aPDT), and antimicrobial blue light (aBL). To describe antimicrobial resistance mechanisms and to present potential light-based alternatives to conventional antimicrobials. The paper was divided into different topics, starting with an approach to antimicrobial resistance mechanisms.

Abstract Prospective, parallel, randomized, double-blind, clinical trial. Participants were at least 30 years old, who were systemically healthy, with stages III-IV, grades B-C periodontitis. Of the 50 eligible individuals for the study, 40 were divided into 2 equal groups. The test group received doses of 500 mg of metronidazole, while the control group received a placebo, both administered three times a day for 7 days, commencing immediately after periodontal surgery.