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Articles by Sergio Escamilla
GluN2A-mediated currents and calcium signal in human iPSC-derived neurons - Scientific Reports
Abstract Gene expression data indicate that during human brain development, neurons change the NMDA receptor (NMDAR) subunit composition to modulate their function, favouring the GluN2A subunit over GluN2B—a hallmark of neuronal maturation. However, evidence supporting this phenomenon in human iPSC-derived neurons remains elusive.
Thyroid hormone promotes fetal neurogenesis
ResearchEndocrinologyNeuroscience Open Access | 10.1172/jci.insight.194445 JCI Insight. https://doi.org/10.1172/jci.insight.194445. Copyright © 2025, Salas-Lucia et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients
1 BACKGROUND N-Methyl-D-aspartate receptors (NMDARs), cation channels gated by the neurotransmitter glutamate, are essential mediators of synaptic transmission and many forms of synaptic plasticity.1 NMDARs displays unique properties that depend on their subunit composition, but few studies have employed human brain tissues to examine their distribution.1 Furthermore, the characterization of NMDAR diversity under neuropathological conditions such as Alzheimer´s disease (AD) has not been fully...
NMDARs in Alzheimer’s Disease: Between Synaptic and Extrasynaptic Membranes
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Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie the Allan-Herndon-Dudley syndrome
ResearchEndocrinologyNeuroscience Open Access | 10.1172/jci.insight.174645 JCI Insight. https://doi.org/10.1172/jci.insight.174645. Copyright © 2024, Salas-Lucia et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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