Sergo Vashakidze on Muck Rack

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Articles

Genetic diversity within diagnostic sputum samples is mirrored in the culture of Mycobacterium tuberculosis

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By Galo Goig, Manuela Torres-Puente, Sergo Vashakidze, Carla Mariner-Llicer
| biorxiv.org
Abstract Culturing Mycobacterium tuberculosis (MTB) from tuberculosis cases is the basis for many research and clinical applications. Paradoxically, it is assumed to impose a diversity bottleneck, which, if true, would entail unexplored consequences. The alternative, culture-free sequencing from diagnostic samples, is a promising but challenging approach both to obtain and analyse the MTB genome from the complex sample.
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