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Thrombolytic therapy for the treatment of acute ischaemic stroke in adults with homozygous sickle cell disease

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By David Calvet, Loubna Majhadi, Servicede Neurologie, Charlotte Rosso
| bmj.com
Stroke is a significant cause of morbidity and mortality in patients with homozygous sickle cell disease (SCD). A specific large-vessel vasculopathy is often responsible for both haemorrhagic and ischaemic strokes in patients with SCD. Although intravenous thrombolysis has been considered as a therapeutic option for acute ischaemic strokes in SCD, its use remains debated because of an increased risk of spontaneous intracranial haemorrhage reported in this disease.
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