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Seu-Na Lee

As seen in: Nature
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Articles

Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel - Nature Communications

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By Seu-Na Lee, Hyeongseop Jeong, Hyuk-Joon Lee, Jae-Sung Woo
| Nature Verified
Abstract Connexin 36 (Cx36) is responsible for signal transmission in electrical synapses by forming interneuronal gap junctions. Despite the critical role of Cx36 in normal brain function, the molecular architecture of the Cx36 gap junction channel (GJC) is unknown. Here, we determine cryo-electron microscopy structures of Cx36 GJC at 2.2–3.6 Å resolutions, revealing a dynamic equilibrium between its closed and open states.
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Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM - Nature Communications

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By Hyuk-Joon Lee, Hyeongseop Jeong, Hyung Jin Cha, Seu-Na Lee
| Nature Verified
Abstract Connexin family proteins assemble into hexameric hemichannels in the cell membrane. The hemichannels dock together between two adjacent membranes to form gap junction intercellular channels (GJIChs). We report the cryo-electron microscopy structures of Cx43 GJICh, revealing the dynamic equilibrium state of various channel conformations in detergents and lipid nanodiscs.
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