Seul-Gi Kim on Muck Rack

Seul-Gi Kim

As seen in: Nature, MDPI, Télé Loisirs
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Articles

JPI-547, a novel dual inhibitor of PARP1/2 and tankyrase is more effective than first-generation PARP inhibitors in preclinical BRCA1/2-mutated cancer models

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By Nar Bahadur Katuwal, Mithun Kumar Ghosh, Yeong Gyu Jeong, Seong Min Park, Tae Kim, Seul-Gi Kim, Seung Ryeol Lee
| Nature Verified
Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors are highly effective therapies for BRCA1/2-mutated tumors. However, most patients eventually develop acquired resistance. Here, we report that JPI-547, a second-generation PARP inhibitor targeting both PARP1/2 and tankyrase, demonstrates potent antitumor activity in olaparib-sensitive and resistant BRCA1/2 mutant models.
Open in Who Shared Issue with article?

Impact of Coronavirus Disease 2019 on Unresectable Hepatocellular Carcinoma Treated with Atezolizumab/Bevacizumab

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By Yun Beom Sang, Seul-Gi Kim, Boyoung Lee, Chaeryoung Lee
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer

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By Mithun Kumar Ghosh, Nar Bahadur Katuwal, Yeong Gyu Jeong, Seul-Gi Kim
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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