Seung-Yeul Lee

Formulation of Lipid Nanoparticles Containing Ginsenoside Rg2 and Protopanaxadiol for the Highly Efficient Delivery of mRNA Lipid nanoparticles (LNPs) are widely recognized as crucial carriers for mRNA in therapeutic and vaccine development. The typical lipid composition for mRNA-LNP systems includes an ionizable lipid, a helper lipid, a polyethylene glycol (PEG)-lipid, and cholesterol.

1. Introduction In recent decades, nanomaterials have played significant roles in the field of nanobiotechnology, such as drug delivery systems, gene delivery carriers, imaging agents, and so on [1,2,3,4,5,6]. However, several significant concerns have emerged related to biocompatibility, toxicity, and the stability of nanoparticles, which means it potentially restricts their suitability for applications in the field of nanobiotechnology [7,8,9,10].