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Seungje Jeon on Muck Rack

Seungje Jeon

As seen in: BioRxiv
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Articles

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface

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By John D. Hulleman, Sofia Bali, Sophia M. DiCesare, Seungje Jeon
| BioRxiv
Abstract High-temperature requirement protein A1 (HTRA1) is a secreted serine protease with diverse substrates, including extracellular matrix proteins, proteins involved in amyloid deposition, and growth factors. Accordingly, HTRA1 has been implicated in a variety of neurodegenerative diseases including a leading cause of blindness in the elderly, age-related macular degeneration (AMD).
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