Seungyoun Kim on Muck Rack

Seungyoun Kim

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Articles

Oncolytic adenovirus in combination with PD-L1-targeted radioimmunotherapy exerts synergistic antitumor effect against pancreatic cancer

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By A-Rum Yoon, Ji Ho Yi, Seungyoun Kim
| The BMJ Verified
Pancreatic cancer remains difficult to treat due to its highly desmoplastic nature and its immune-desert phenotype. We have proposed novel strategies combining HY-oncolytic adenovirus (oAd) expressing interleukin-12, granulocyte macrophage colony-stimulating factor, and relaxin with programmed death-ligand 1 (PD-L1) targeted radioimmune therapy, which can reprogram the hostile tumor microenvironment of pancreatic tumors.
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