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Sha Zhu on Muck Rack

Sha Zhu

As seen in: Nature, Wiley Online Library, Elsevier, Frontiers, Frontiers in Immunology, MDPI, Genome Medicine, Molecular Cancer, Science Magazine, Royal Society of Chemistry and
Farther, husband, programmer, data scientist, 🐶 lover. Made in China, built in NZ, upgraded in Oxford. ex-BDI, ex-BGI. Views of my own
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Articles

Establishment of a scalable engineered cell-line platform for direct, GMP-grade production of eVLP vectors enabling streamlined generation of gene-edited CAR-T/NK cells

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By Wei Lin, Jiaru Shi, Hanyi Chen, Sha Zhu, Lili Chen, Zhengbo Wang, Yaru Feng, Lijun Zhao, Junhui Chen, Guohua Yu, Tao Lu, Jianxun Wang, Ruikai Chai, Shengshui Mo, Huaxiu Li
| Frontiers in Immunology
Abstract Introduction: CRISPR–Cas9 has transformed the engineering of chimeric antigen receptor T (CAR-T) cells and chimeric antigen receptor NK (CAR-NK) cells; however, its clinical translation remains constrained by the high cost, batch-to-batch variability, and stringent regulatory requirements associated with current viral and electroporation-based manufacturing approaches.
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Impact of Social and Structural Determinants of Health on Bladder Cancer Outcomes: Focus on Non-Muscle-Invasive Disease.

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By Sha Zhu, Samuel L. Washington, Rishi R. Sekar
| UroToday Verified
Non-muscle-invasive bladder cancer (NMIBC) requires repeated procedures, long-term surveillance, and sustained access to urologic care. Outcomes are highly sensitive to health disparities. This article examines how social determinants of health including insurance status, socioeconomic factors, gender, ethnicity, geography, and care fragmentation can impact NMIBC care.
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Intravenous administration of an engineered AAV9-gene-silencing vector suppresses human SOD1 and extends survival in an ALS mouse model

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By Fang Wan, Jinchen He, Hong Ma, Débora Ferreira, Veena Kumanan, Ji Sun Lee, Xiupeng Chen, Ran He, Qin Su, Thomas Gallagher, Sha Zhu, Gabriela Cabrera, Lingzhi Zhao, Robert Brown Jr., Robert H. Jr., Zuoshang Xu, Guangping Gao, Jun Xie, Joan Shen, Alisha Gruntman
| Nature Verified
Abstract Adeno-associated virus (AAV)-mediated gene silencing offers a promising strategy for achieving durable therapeutic effects with a single administration. Mutations in the human superoxide dismutase 1 (hSOD1) gene, inherited in an autosomal dominant manner, lead to motor neuron degeneration in amyotrophic lateral sclerosis (ALS)—a fatal neurodegenerative disease with no effective treatment.
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