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Shadi Sedghi Masoud

As seen in: Cell Chemical Biology
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Articles

Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne-Nitrone Cycloadditions Involving Dibenzocyclooctadiyne

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By Kaitlyn D Margison, Shadi Sedghi Masoud, Masaya Nakajima, Didier A. Bilodeau
| dx.doi.org
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Chem. Biol. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite

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By Yasushi Takemoto, Aileen Mendoza, Kevin Tan Cruzado, Shadi Sedghi Masoud
| Cell Chemical Biology Verified
Highlights • Lactone-vitamin D3 binds to HADHA. • Lactone-vitamin D3 inhibits the binding of TMLD and HADHA. • Lactone-vitamin D3 limits TMLD function and subsequent carnitine synthesis. • Lactone-vitamin D3 impairs fatty acid β-oxidation. Summary Lactone-vitamin D3 is a major metabolite of vitamin D3, a lipophilic vitamin biosynthesized in numerous life forms by sunlight exposure. Although lactone-vitamin D3 was discovered 40 years ago, its biological role remains largely unknown.
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