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Shadil Ibrahim Wani on Muck Rack

Shadil Ibrahim Wani

As seen in: Nature, MDPI
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Articles

Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments

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By Naoya Kitamura, Mayumi Iwatake, Satoshi Mizoguchi, Shadil Ibrahim Wani, Muhammad Hasnain, Van Nguyen, Văn Nguyễn, Ryo Yokoyama, Toshihiro Ojima, Koichiro Shimoyama, Kenichi Hirabayashi, Yoshitomo Morinaga, Tomoshi Tsuchiya, Komei Kobayashi, Naru Kitade, Naoya Koba, Hideki Hatta
| Nature Verified
Abstract Two-dimensional (2D) culture models are commonly used in cancer research, but fail to recapitulate complex mechanical cues of native tissues. In this study, we developed an ex vivo three-dimensional (3D) lung cancer model by seeding human lung adenocarcinoma cells into decellularised rat lungs and culturing them in a pressure chamber and perfusion system mimicking respiratory motion (RM) and blood flow.
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