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Shahong Di on Muck Rack

Shahong Di

As seen in: Frontiers in Immunology
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Articles

Virtual screening identifies specnuezhenide as a potential therapeutic agent for rosacea via KLK5/TLR4/NF-κB pathway inhibition and metabolic modulation

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By Jingang Xu, Xinyu Li, Manyu Chen, Yao Zhang, Yueye Xu, Boya Xu, Junjie U Guo, Jingyun Xu, Yuanyuan Li, Jinhong Zhao, Shahong Di
| Frontiers in Immunology
Abstract Background: Rosacea is a chronic inflammatory skin condition. Excessive LL-37 is produced when serine protease kallikrein-5 (KLK5) is hyperactivated, contributing to the inflammatory response in rosacea. Thus, inhibition of KLK5 has the potential to attenuate inflammation in this condition. Reports suggest that specnuezhenide (Spe), an isomer of oleanolic acid, is effective as an anti-inflammatory agent for the treatment of inflammatory diseases.
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