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Keywords RNA methylation Nsp16 Nsp10 RNA capping Introduction Coronaviruses (CoVs) modify 2′-OH of ribose sugar of the first transcribed nucleotide (N1) to protect their mRNA from degradation and host innate immune recognition.1 The N1 base (usually A1 in CoVs, A1/G1 in other RNA viruses) is enzymatically modified with the sequential attachment of an RNA cap and its subsequent methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases.2,3 The capping of SARS-CoV-2 mRNA includes...
Abstract The mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to lymphomagenesis is unknown. We modeled IRF8 variants in B cell lymphomas and found that they affected the expression of regulators of antigen presentation.
Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 illness, has caused millions of infections worldwide. In SARS coronaviruses, the non-structural protein 16 (nsp16), in conjunction with nsp10, methylates the 5′-end of virally encoded mRNAs to mimic cellular mRNAs, thus protecting the virus from host innate immune restriction.
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