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Shailesh Gupta

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Articles

NEPRO forms fibrous scaffolds in the nucleolus to maintain nucleolar integrity and orchestrate ribosome biogenesis

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By Abhishek Kumar, Shailesh Gupta, Yogendra Pratap Mathuria
| Wiley Online Library Verified
Abhishek Kumar and Shailesh Kumar Gupta contributed equally. CONFLICT OF INTEREST STATEMENT The authors declare no competing financial or non-financial interests. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. REFERENCES , , , , , , et al. Nucleolar proteome dynamics. Nature. 2005; 433(7021): 77–83. , , , , . The nucleolus under stress. Mol Cell. 2010; 40(2): 216–227. , , , , , , et al.
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Hybrid deep learning novel framework for classification of parkinson’s disease - Scientific Reports

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By Shivani Desai, Smit Shah, Kanisha Shah, Tarjni Vyas, Anuja Nair, Pranshav Gajjar, Shailesh Gupta, Riki Patel, Harshal Sanghvi, Meet Vora, Hitesh Chhikaniwala
| Nature Verified
Abstract Parkinson’s disease is a progressive neurodegenerative disorder that primarily affects the motor system and is often difficult to diagnose in its early stages due to subtle and age-overlapping symptoms. To address this challenge, we propose a hybrid deep learning-based diagnostic framework using T2-weighted MRI scans from the PPMI dataset consisting of 77 healthy control (HC) and 223 Parkinson’s disease (PD) subjects.
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Truncating GAS6 Variant Disrupts Neuroglial Homeostasis in a Childhood‐Onset Demyelinating Disorder

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By Abhishek Kumar, Vishal Gaurav, Yogendra Pratap Mathuria, Shailesh Gupta
| Wiley Online Library Verified
Growth arrest–specific 6 (GAS6) protein is required for cell survival through its role in TAM receptor signalling. Here, we investigate a novel autosomal recessive demyelinating disorder in a 9-year-old male presenting with progressive motor dysfunction, spasticity, seizures and cognitive decline. MRI revealed multifocal T2/FLAIR hyperintensities in periventricular, juxtacortical and brainstem white matter regions.
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