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Shalil Khanal

As seen in: Nature, Science Magazine
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Articles

Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis

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By Alison G. Paquette, David T. Schultner, Delin Liu, Shalil Khanal
| Science Magazine Verified
Abstract Liver fibrosis is characterized by the activation of perivascular hepatic stellate cells (HSCs), the release of fibrogenic nanosized extracellular vesicles (EVs), and increased HSC glycolysis. Nevertheless, how glycolysis in HSCs coordinates fibrosis amplification through tissue zone-specific pathways remains elusive. Here, we demonstrate that HSC-specific genetic inhibition of glycolysis reduced liver fibrosis.
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Nano-fibre Integrated Microcapsules: A Nano-in-Micro Platform for 3D Cell Culture

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By Shalil Khanal, Shanta R. Bhattarai, Jagannathan Sankar, Ramji K. Bhandari
| Nature Verified
Abstract Nano-in-micro (NIM) system is a promising approach to enhance the performance of devices for a wide range of applications in disease treatment and tissue regeneration. In this study, polymeric nanofibre-integrated alginate (PNA) hydrogel microcapsules were designed using NIM technology. Various ratios of cryo-ground poly (lactide-co-glycolide) (PLGA) nanofibres (CPN) were incorporated into PNA hydrogel microcapsule.
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