Shams Aaghaz

Neurodegenerative diseases have a tremendous impact on the health of the global population with ∼ 24 million people diagnosed worldwide, and an estimated economic cost of $100 billion dollars a year in the USA alone.[1, 2] In many cases neurodegeneration is highly correlated with protein aggregation,[2-6] yet the biological function and toxicity mechanism of protein aggregates observed in the pathological state is not completely understood.[4, 5] Previously, we have discovered that...

1 Introduction Cyclization reaction in organic synthesis is an effective pathway to construct small molecules with requisite molecular complexity. Several heterocyclic and carbocyclic frameworks are efficiently synthesized by cyclization of simple cyclic/acyclic precursors.1 In this context, 1,3-enynes emerged as one of the favorite substrates in the advancement of efficient cyclization methodologies.

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Komal Sharma 1, Shams Aaghaz 1, Indresh Kumar Maurya 2, Shreya Singh 3, Shivaprakash M.