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Shangying Chen

As seen in: Nature, Bioanalysis
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Articles

DNA methylation signatures distinguish extranodal NK/T-cell lymphoma and EBV-positive nodal T/NK-cell lymphoma and identify prognostic subgroups

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By Shangying Chen, Wenjun Gu, Anja Fischer, Qiao-Yang Sun, Henry Yang, Nicholas Syn, Shih-Sung Chuang, Seiichi Kato, Joseph Khoury, Young-Hyeh Ko, Limei Poon, Leticia Quintanilla-Martínez, Reiner Siebert, Ling-Wen Ding, Siok-Bian Ng, Lichang Deng
| Nature Verified
Abstract Extranodal NK/T-cell lymphoma (ENKTL) and primary Epstein–Barr virus (EBV)-positive nodal T/NK-cell lymphoma (nodal-TNKL) are aggressive lymphomas with overlapping clinicopathologic features but distinct underlying biology. While their genomic landscapes have been increasingly defined, comparative epigenetic characterization remains limited.
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Discovery of novel dual VEGFR2 and Src inhibitors using a multistep virtual screening approach

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By Xuan Yang, Shangying Chen, Chu Qin, Lin Tao
| Bioanalysis Verified
Aim: Simultaneous inhibition of VEGFR2 and Src may enhance the efficacy of VEGFR2-targeted cancer therapeutics. Hence, development of dual inhibitors on VEGFR2 and Src can be a useful strategy for such treatments.
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