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Shanhu Hu

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Articles

TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network

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By Shunyi Zhao, Valentina C. Sladky, Rémi Blinder, Taylor Jones Verified, Junjie Feng, Olivia Luyties, Kira Cozzolino, Lynn Sanford, Christopher C. Ebmeier, Grace S. Shelby, Lotte Watts, Jessica Rodino, Nisha Rajagopal, Shanhu Hu, Finn Brennan, Zachary L. Maas, William Richter, Jenna K. Rimel, Sydney Alnemy
| Science Magazine Verified
Abstract How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution cryo–electron microscopy revealed how two clinically relevant inhibitors block CDK7 function. In cells, CDK7 inhibition rapidly suppressed transcription, but constitutively active genes were disproportionately affected versus stimulus-responsive. Distinct transcription factors (TFs) regulate constitutive versus stimulus-responsive genes.
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Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7

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By Shanhu Hu, Jason J Marineau, Nisha Rajagopal, Kristin B Hamman
| cancerres.aacrjournals.org
Translational Science Shanhu Hu, Jason J. Marineau, Nisha Rajagopal, Kristin B. Hamman, Yoon Jong Choi, Darby R. Schmidt, Nan Ke, Liv Johannessen, Michael J. Bradley, David A. Orlando, Sydney R. Alnemy, Yixuan Ren, Stephane Ciblat, Dana K. Winter, Anzhelika Kabro, Kevin T. Sprott, J. Graeme Hodgson, Christian C. Fritz, John P. Carulli, Emmanuelle di Tomaso and Eric R.
Open in Who Shared Issue with article?

Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7

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By Shanhu Hu, Jason J Marineau, Nisha Rajagopal, Kristin B Hamman
| cancerres.aacrjournals.org
Research Article Shanhu Hu, Jason J Marineau, Nisha Rajagopal, Kristin B Hamman, Yoon Jong Choi, Darby R Schmidt, Nan Ke, Liv Johannessen, Michael J Bradley, David A Orlando, Sydney R Alnemy, Yixuan Ren, Stephane Ciblat, Dana K Winter, Anzhelika Kabro, Kevin T Sprott, J.
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