Shaniko Kaleci

1 Introduction Melanoma diagnosis has been improved by recognition of specific dermoscopic structures [1]. Negative pigment network (NPN) is a dermoscopic structure defined as ‘serpiginous, interconnecting, hypopigmented lines that surround irregularly shaped brown structures, which resemble elongated and curvilinear globular structures’ [2, 3]. The presence of NPN has high specificity (95%), albeit low sensitivity (22%), for melanoma diagnosis [4, 5].

1 Introduction In recent years, JAK inhibitors have been approved in many countries for the treatment of psoriasis, atopic dermatitis, alopecia areata (AA), and vitiligo, representing a promising therapeutic approach for various skin conditions [1-3]. Despite their efficacy, oral JAK inhibitors have been associated with significant adverse events, including major cardiovascular and thromboembolic events, systemic infections, and malignancies [1, 3-5].

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