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Shanmuga Sozhamannan on Muck Rack

Shanmuga Sozhamannan

As seen in: Nature, Global Biodefense
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Articles

Multi-feature classification to improve colorimetric loop-mediated isothermal amplification fidelity

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By Daniel Negron, Kelsey Hauser, Nicholas Tolli, Shanmuga Sozhamannan, Bradley Abramson, Gabrielle Melton, Sveta Jagannathan, Katharine Jennings, Bryan D. Necciai
| Nature Verified
Abstract Loop-mediated isothermal amplification (LAMP) is a cost-effective and portable assay technique for performing nucleic acid-based diagnostics in the field whose adoption is hindered by design and reproducibility issues. This is due to a complex primer design process that fine-tunes parameters across 6–8 binding regions.
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Are We There Yet? Agent Agnostic Metagenome Sequencing for Biothreat Detection

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By Shanmuga Sozhamannan, Ph. D
| Global Biodefense
For decades real-time polymerase chain reaction (PCR) has been the gold standard for biothreat detection across the enterprise engaged in biodefense. For example, the Department of Defense (DoD) Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), Defense Biological Product Assurance Office (DBPAO) maintains a portfolio of 46 real-time PCR assays targeting 21 biological warfare agent organisms.
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