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SGLT2 inhibitors and the risk of incident chronic kidney disease in type 2 diabetes: a nationwide emulated target trial in Taiwan
Keywords Macroalbuminuria Dialysis Acute kidney injury Cardiovascular events All-cause mortality Abbreviations T2D (type 2 diabetes) CKD (chronic kidney disease) eGFR (estimated glomerular filtration rate) UACR (urinary albumin-to-creatinine ratio) UPCR (urine protein-creatinine ratio) SGLT2 (sodium-glucose cotransporter 2) ACEI (angiotensin-converting enzyme inhibitors) ARB (angiotensin receptor blocker) GLP-1 RA (glucagon-like peptide-1 receptor agonists) HbA1c (hemoglobin A1C) Get full...
Comparative outcomes of adding SGLT2 inhibitors versus incretin-based therapies to insulin in type 2 diabetes
Keywords Coronary artery disease Stroke Heart failure End-stage kidney disease Sight-threatening retinopathy Amputation All-cause mortality Abbreviations T2D (type 2 diabetes) SGLT2 (sodium-glucose cotransporter-2) GLP-1RA (glucagon-like peptide-1 receptor agonist) DPP-4 (dipeptidyl peptidase-4) CAD (coronary artery disease) MACE (major adverse cardiovascular events) ESKD (end-stage kidney disease) OADs (oral antidiabetic drugs) Get full text access Log in, subscribe or purchase for full access.
Outcomes of second-line oral antidiabetic drugs in persons with young-onset type 2 diabetes
Highlights • Add-on DPP-4 inhibitors is associated with lower risks of all-cause hospitalization. • Add-on DPP-4 inhibitors is associated with lower risks of all-cause mortality. • DPP-4 inhibitors seem to be a suitable second-line OAD for patients for YOD. Abstract Aim People with young-onset diabetes (YOD) exhibit a higher risk of morbidity and mortality than those with late-onset diabetes. Few studies have explored the preferred management of diabetes in such patients.
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