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Shaoya Yin on Muck Rack

Shaoya Yin

As seen in: Nature
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Targeting MEF2A suppresses microglial hyperactivation and synaptic phagocytosis to attenuate epilepsy pathogenesis

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By Jingheng Wu, Jiayuanyuan Fu, Shuai Wang, Yuzhang Wu, Xu Wang, Qi Shi, Yuhao Wang, Yetong Shi, Yehong Fang, Yu Lan, Qiaoli Wu, Chuan Du, Lixia Xu, Hua Yan, Shangang Feng, Shaoya Yin
| Nature Verified
Abstract Microglia’s role in epilepsy through neuroimmune communication is poorly understood. Mechanisms by which neurons activate microglia and how microglia affect neuronal activity to drive seizure-related inflammation remain unclear. Here, we elucidated a crucial axis connecting pathological adenosine triphosphate (ATP) release induced by epileptiform neuronal activity to microglial MEF2A-dependent hyperactivation, which exacerbates epilepsy pathology.
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