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Shaoying Lu on Muck Rack

Shaoying Lu

As seen in: Nature, BioRxiv, Annals of Vascular Surgery
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Articles

Multiplexed live imaging deciphers nuclear force-driven chromatin dynamics and embryo development

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By Jinfeng Wang, Juhui Qiu, Yanjing Zhao, Mengqi Yang, Shaoying Lu, Saiyang Ding, Yanfeng Luo, Kun Sun, Shu Chien, Jing Zhou, Qin Peng, Yafan Xie, Fangning Xu
| Nature Verified
Abstract Mechanical forces transmitted to the nucleus regulate chromatin organization and gene expression to guide cell fate transitions. However, how the forces dynamically reshape the genome in living systems remains unclear.
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Dissecting Force Transmission across SUN Proteins Using Nuclear Tension Sensors

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By Jinfeng Wang, Juhui Qiu, Shaoying Lu, Saiyang Ding
| BioRxiv
Abstract Forces on the linker of the nucleoskeleton and cytoskeleton (LINC) complex control nuclear mechano-sensing and mechano-adaptation. However, the force transmission dynamics across the LINC complex are not fully understood, mainly because of the lack of imaging tools. We developed a set of genetically-encoded fluorescence resonance energy transfer (FRET)-based nuclear tension sensors (NuTS) that measure tension forces across SUN1/2 proteins in living cells with high sensitivity.
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