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Shaozhen Yin

As seen in: BioRxiv
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Articles

Oncogenic PIK3CA corrupts growth factor signaling specificity

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By Ralitsa R. Madsen, Margaritis Voliotis, Alix Le Marois, Shaozhen Yin
| BioRxiv
Abstract Pathological activation of the PI3K/AKT pathway is among the most frequent defects in human cancer and is also the cause of rare overgrowth disorders. Yet, there is currently no systematic understanding of the quantitative flow of information within PI3K/AKT signaling and how it is perturbed by disease-causing mutations.
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