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Sharmi Amin on Muck Rack

Sharmi Amin

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Articles

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

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By Jennifer A. Jenks, Amit Kumar, Sharmi Amin, Madeline R. Sponholtz, PLOS Pathogens
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Molecular determinants of gB AD-2S1 linear epitope binding and neutralizing potency To obtain high-resolution information on the binding of the early intermediate mAb I8 to the gB AD-2S1 linear epitope, we conducted crystallographic studies of TRL345.I8 antigen-binding fragment (Fab) in complex with the linear gB AD-2S1 peptide (65-HRANETIYNTTLKYG-79). A crystal in the space group P212121 with one complex per asymmetric unit diffracted X-rays to a resolution of 1.8 Å.
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