Sharvari Mankame on Muck Rack

Sharvari Mankame

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Articles

Cell-Free DNA Reveals the Longitudinal Effects of Temozolomide Treatment and Host Co-Culture in Glioblastoma Models

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By Sharvari Mankame, Maria Kyriakidou, Nanyun Tang, Hersh Nanda
| biorxiv.org
Abstract Glioblastoma (GBM) is a highly aggressive brain tumor with limited options for longitudinal monitoring. We evaluated the potential of cell-free DNA (cfDNA) as a real-time biomarker of tumor burden under tightly controlled conditions. We measured the cfDNA release dynamics, fragmentation sizes, and variant allele frequencies (VAF) in patient-derived GBM cell cultures.
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