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Shashikanta Barik on Muck Rack

Shashikanta Barik

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Non-enzymatic error correction in self-replicators without extraneous energy supply - Scientific Reports

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By Koushik Ghosh, Parthasarthi Sahu, Shashikanta Barik, Hemachander Subramanian
| Nature Verified
Abstract Accurate propagation of sequence information in nucleic acids is central to the evolutionary dynamics of self-replicating systems. Modern biological systems achieve high fidelity using enzymes that actively correct errors through energy-driven mechanisms. However, such complex machinery was absent under prebiotic conditions. Here, we present a theoretical model of error correction in self-replicating heteropolymers that requires neither enzymes nor an extraneous energy supply.
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