Shatadal Ghosh

1 Introduction Chlorogenic acid (CGA), alternatively termed as coffee tannic acid and coffee ellagic acid, is a water-soluble phenolic acid synthesized by plants during aerobic respiration (Liu et al., 2020a). This acid arises from the esterification of caffeic acid and quinic acid, boasting a molecular architecture characterized by three labile groups: ester bonds, unsaturated double bonds, and dibasic phenols (Yu et al., 2018).

1 The JAK-STAT signaling pathway: an overview The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is crucial for many vital cellular processes, including the expression of inflammatory mediators. Indeed, the role of JAK-STAT is to transmit, through interaction with transmembrane receptors, information received from extracellular space signals, thereby mediating a downstream message to the nuclear compartment.