Submitted: 06 October 2026 You are already at the latest version RNA editing via adenosine-to-inosine (A-to-I) conversion requires adenosine deaminases acting on RNA (ADAR) and provides a reversible, transcript-level alternative to permanent DNA genome editing. Current strategies rely on the recruitment of endogenous human ADARs with synthetic guide RNAs (arRNAs, AIMers) instead of delivering exogenous Cas-fusion proteins, which reduces immunogenicity and delivery issues.
