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Shayma Abukar on Muck Rack

Shayma Abukar

As seen in: BioRxiv
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Articles

Live-imaging reveals Coordinated Cell Migration and Cardiac Fate Determination during Mammalian Gastrulation.

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By Shayma Abukar, Peter Embacher, Alessandro Cicarrelli, Sunita Varsani-brown
| BioRxiv
Abstract Heart development involves the specification of cardiac progenitors at distinct stages and locations. Using live-imaging of mouse embryos between gastrulation and heart tube formation, we tracked individual mesodermal cells and reconstructed their lineage trees for up to five cell divisions. We found independent unipotent progenitors emerging at specific times, contributing exclusively to either left ventricle/atrioventricular canal (LV/AVC) or atrial myocytes.
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Live-imaging reveals Coordinated Cell Migration and Cardiac Fate Determination during Mammalian Gastrulation.

|
By Peter Embacher, Sunita Varsani-brown, Shayma Abukar, Alessandro Cicarrelli
| BioRxiv
Abstract Heart development involves the specification of distinct sets of cardiac progenitors at various times and locations during ontogeny. Here, we used live imaging in mice from the initiation of gastrulation to heart tube formation stages to investigate the origin and migratory paths of cardiac progenitors. We tracked individual mesodermal cells, reconstructing the lineage tree of the cells and fates for up to four generations.
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